AKT-IN-9,2709045-53-2

Akt/Pkb信号通路图

and p53. Akt is also major mediator of cell survival by directly inhibiting different pro-apoptotic signals such as Bad and the Forkhead family of transcription factors, or indirectly by modulating two central regulators of cell death such as p53 and NF-£

Akt/Pkb信号通路图

and p53. Akt is also major mediator of cell survival by directly inhibiting different pro-apoptotic signals such as Bad and the Forkhead family of transcription factors, or indirectly by modulating two central regulators of cell death such as p53 and NF-£

PI3K/Akt/mTOR信号通路

剂量-时间依赖的抑制HepG2和Hep3B细胞生长。饱和效应浓度的 LY294002和RAPA作用24小时后，HepG2和Hep3B细胞均呈现明显的G0/G1期阻滞，处于S期的细胞比例较对照组显著减少 （P 结论：（1）HepG2和Hep3B细胞存在PI3K/Akt/mTOR信号通路的组成性激活；（2）LY294002和RAPA能有效阻断HepG2和 Hep3B细胞PI3K/Akt/mTOR信号通路，抑制HCC细胞的生长增殖，诱导细胞周期阻滞，促进细胞凋亡，且阻断效应与HCC细胞P53的表达