MIP-3 beta/CCL19 蛋白, Mouse (sf

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MIP-3 beta/CCL19 Protein, Mouse (sf9, His)

MCE 国际站：MIP-3 beta/CCL19 Protein, Mouse (sf9, His)

MIP-3 beta/CCL19 Protein, Mouse (sf9, His) 是一种 CC 趋化因子，对 CD4 T 细胞和 CD8 T 细胞具有强烈趋化性，作为配体可以与趋化因子受体 CCR7 特异性结合，介导组织免疫、炎症反应以及抗病毒感染。MIP-3 beta/CCL19 Protein, Mouse (sf9, His) 是一种由 Sf9 insect cells 表达的重组小鼠 MIP-3 beta/CCL19(M1-S108) 蛋白，C 端带有 his 标签。

Synonyms: C-C motif chemokine 19; SCYA19

Species: Mouse

Source: Sf9 insect cells

研究背景：CCL19, also known as MIP-3 beta, is an immunostable chemokine that is located on chromosome 9 in the human genome. CCL19 is abundantly expressed in the thymus and lymph nodes, moderately expressed in the trachea and colon, and less expressed in the stomach, small intestine, lung, kidney, and spleen. CCL19 binds to and functions as a chemokine receptor, CCR7. CCR7 is the first CCR7 is the first lymphocyte-specific G protein-coupled receptor (GPCR) identified with seven transmembrane alpha helices. CCR7 is expressed on both double-negative and single-positive thymocytes, including naive T cells, central memory T cells, regulatory T cells, naive B cells, semimature/mature DCs and NK cells, as well as a few tumor cells, where it serves as a key regulator for directing steady-state lymphocytes to secondary lymphoid organs. In contrast, CCL19 is the only chemokine known to effectively stimulate β-arrestin-mediated phosphorylation and internalization of CCR7, leading to receptor desensitization and migration of antigen (Ag)-presenting DCs, thereby affecting T cell responses. The CCL19-CCR7-based signaling pathway plays an important role in tissue immunity and inflammatory response memory. In addition, it also plays a role in vaccine-based protection against a variety of viruses, such as HIV-1 infection, hepatitis C virus (HCV), and herpes simplex virus 1 (HSV-1), etc. The interaction of CCL19 and CCR7 also contributes to the release of antiviral-associated cytokines (e.g., IFN-γ and IL-4) by immune cells, thereby promoting T cell proliferation and DC uptake of antigens.

蛋白编号：O70460 (M1-S108)

基因 ID：24047

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL19

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  MIP-3 beta/CCL19

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