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- 近岸蛋白(Novoprotein)
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- DC010
- 2025年11月10日
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Human PTH (诊断原料,其它）
Recombinant Human PTH
Catalog #: DC010 Derived From: E.coli
Description:
Recombinant Human Parathyroid Hormone/Parathormone/PTH is produced by E.coli expression system and the target gene encoding Ser32-Gln115 is expressed.
Accession: P01270
Names(Known as):Parathyroid Hormone; PTH; Parathormone; Parathyrin
Quality Control:
Mol Mass: 9kDa AP Mol Mass: 14kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μm filtered solution of 10mM HAc-NaAc, 150mM NaCl, 5% Mannitol, pH 4.0.
Shipping:
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Ion-exchange chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone. After intracellular processing, the mature hormone is packaged within the Golgi into secretory vesicles, the secreted into blood by exocytosis. Parathyroid hormone is secreted as a linear protein of 84 amino acids.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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文献和实验北京时间 2022 年 2 月 9 日，中国科学院深圳先进技术研究院脑认知与脑疾病研究所、深港脑科学创新研究院杨帆课题组在 Nature Communications 上发表题为 An optogenetic approach for regulating human parathyroid hormone secretion 的最新研究成果。 研究团队历时 5 年，创新性地将光遗传技术运用于甲状旁腺素（Parathyroid Hormone, PTH）的分泌调控，通过精准节律性调节
甲状腺激素对细胞核RNA合成的影响生理科学进展 1989；20：363-365 6．马青年 近年内分泌学基础研究值得注意的几个方面生理通讯 1992；11：3�5 7．朱岩，邱学才 糖皮质激素“允许作用”的可能机制生理科学进展1993；24：263�226 8．Fukayma s et al.Human parthyroid hirmone(PTH)-related protein and human PTH:comparative biological
根据《Nature》统计，近 80% 的生物学家无法重复他人的实验结果，60% 无法重复自己的实验结果[1]。Human Protein Atlas Project 曾经检验了 9 000 种来自 29 家供应商的抗体产品，超过 50% 的产品无法有效工作。据不完全统计，在美国和全世界使用特征不明确的抗体每年分别浪费的经费高达 3.5 亿和 8 亿美元，而这样的抗体将会导致实验失败或结果不可靠，加剧抗体研究的「重复危机」。因此在 2016 年为了刺激研究界实现更高标准的抗体重复性，国际抗体
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