Human PRL (诊断原料,生殖）

Recombinant Human PRL (C-6His)

 

Catalog #:  DCM10        Derived From: Human Cells   

 

Description:

Recombinant Human Prolactin is produced by our Mammalian expression system and the target gene encoding Leu29-Cys227 is expressed with a 6His tag at the C-terminus.

Accession:  P01236

Names(Known as): Prolactin; PRL

 

Quality Control:

Mol Mass:  23.9kDa                  AP Mol Mass:  25-30 kDa, reducing conditions

Purity:  Greater than 95% as determined by reducing SDS-PAGE.

 

Formulation:

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

 

Shipping:

The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.

 

Storage:

Reconstituted protein solution should be stored at ≤ -20°C.

 

Purification: 
Affinity purification chromatography.

 

Immunoreactivity: 
N.A.

 

Application:
Immunogen, calibrator or standard.

 

Background:

Prolactin (PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary glandto promote lactation, but has pleiotropic effects in both males and females. Non-glycosylated prolactin isproduced by the pituitary and packaged in storage granules before secretion, while glycosylated prolactin isreported to be constitutively secreted, have lower biological potency, and be removed from the circulationmore quickly. Prolactin is synthesized mainly by the anterior pituitary in all mammals, where secretion isunder tonic inhibition by hypothalamic dopamine. In humans, prolactin is also produced peripherally.Prolactin expression is low during early human pregnancy, but increases in late pregnancy. The prolactinreceptor (PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoieticreceptor family. prolactin molecule is thought to bind two receptor molecules. In addition to its lactogenicactivity, peripherally produced prolactin plays roles in breast and prostate cancer development, regulationof reproductive function, and immunoregulation.

 

FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY