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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20°C/-80°C
- 保质期:
12个月
- 英文名:
Recombinant Human Interleukin-36 gamma(IL36G)
- 库存:
4
- 供应商:
上海禾午生物科技有限公司
- 规格:
20ug/100ug/1mg
产品详情
纯度:>95% as determined by SDS-PAGE and HPLC.
内毒素:Less than 1.0 EU/μg as determined by LAL method.
生物活性:Fully biologically active when compared to standard. The ED50 as determined by its ability to induce IL-8 secretion by human preadipocytes is less than 10 ng/ml, corresponding to a specific activity of >1x105 IU/mg.
基因名:IL36G
Uniprot No.:Q9NZH8
别名:IL 1 epsilon; IL 1 related protein 2; IL 1(EPSILON); IL 1F9; IL 1H1; IL 1RP2; IL-1 epsilon; IL-1-related protein 2; IL-1F9; IL-1H1; IL-1RP2; IL1E; Il1f9; IL1F9_HUMAN; IL1H1; IL1RP2; IL36 gamma; IL36G; Interleukin 1 epsilon; Interleukin 1 family member 9; Interleukin 1 homolog 1; Interleukin 1 related protein 2; Interleukin 36 gamma; Interleukin-1 epsilon; Interleukin-1 family member 9; Interleukin-1 homolog 1
种属:Homo sapiens (Human)
蛋白长度:Full Length of Mature Protein
来源:E.Coli
分子量:17.0 kDa
表达区域:18-169aa
蛋白标签:Tag-Free
产品提供形式:Liquid or Lyophilized powder
功能:与IL1RL2/IL-36R受体结合并通过IL1RL2/IL-36R受体发出信号,进而激活靶细胞中的NF-kappa-B和MAPK信号通路。部分IL-36信号系统,被认为存在于上皮屏障中并参与局部炎症反应;类似于IL-1系统,它与共同受体IL1RAP共享。通过作用于角化细胞、树突状细胞和间接作用于t细胞,促进组织浸润、细胞成熟和细胞增殖,似乎参与了皮肤炎症反应。在培养的角质形成细胞中诱导巨噬细胞、t细胞和中性粒细胞趋化因子如CCL3、CCL4、CCL5、CCL2、CCL17、CCL22、CL20、CCL5、CCL2、CCL17、CCL22、CXCL8、CCL20和CXCL1的表达;也刺激其自身和皮肤的原型促炎参数TNF-alpha、S100A7/银屑病素和诱导性NOS的表达。可能在特定的中性粒细胞气道炎症反应中发挥促炎作用:激活原肺成纤维细胞的丝裂原活化蛋白激酶和NF-kappa B,并刺激肺成纤维细胞IL-8、CXCL3和Th17趋化因子CCL20的表达。可能参与对真菌病原体的先天免疫反应,如烟曲霉。
更多活性蛋白请浏览上海禾午生物科技有限公司
上海禾午生物科技有限公司 提供重组蛋白生产服务 His、GST、MBP等多种表达方式同时进行,确保获得蛋白
蛋白表达与纯化服务 纯化的蛋白经过ELISA,Western-blot,或者其它生物活性验证 标签切除 测序报告
上海禾午生物科技有限公司是一家生物高新技术企业,产品覆盖分子生物学、细胞生物学、生物学试剂、标准物质,等领域。以研发、销售为核心致力于生命科学产品。已与全国各大科研院校、医院、企业以及国外一些科研机构有良好的合作关系。
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