Bexirestrant,2505067-70-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Bexirestrant

CAS No. : 2505067-70-7

MCE 国际站：Bexirestrant

产品活性：Bexirestrant 是一种具有口服活性的 ER-α 降解剂。Bexirestrant 可用于抗雌激素、抗肿瘤的研究。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：Estrogen Receptor/ERR

In Vitro: Bexirestrant (compound Formula Ia) inhibits the growth of wild type (WT), Y537S and D538G mutated MCF-7 cells with IC₅₀s of 0.3. 6.0, 2.2 nM, respectively.
Bexirestrant induces the ER-α degradation in WT, Y537S and D538G mutated MCF-7 cells with IC₅₀s of 0.3. 19.6, 12.7 nM, respectively.
Bexirestrant shows 16.3% ER-α remaining in WT MCF-7 cells at concentration of 1 nM.

In Vivo: Bexirestrant (50mg/kg; p.o.; 28 days) shows a good efficacy in an MCF-Y537S xenograft.Pharmacokinetic parameters in rat at 50 mg/kg p.o. dose：

Tmax (h)	Cmax (ng/mL)	AUClast (hr× ng/mL)	AUCinf_obs (hr×ng/mL)	T1/2 (h)
4.00	343	7582	9804	26

相关产品：Tamoxifen  |  Estradiol  |  Fulvestrant  |  4-Hydroxytamoxifen  |  Cholesterol  |  Kaempferol  |  G15  |  G-1  |  Vepdegestrant  |  PHTPP  |  Elacestrant  |  27-Hydroxycholesterol  |  Estrone  |  Raloxifene hydrochloride  |  DPN  |  Camizestrant  |  Propyl pyrazole triol  |  XCT790  |  Liquiritigenin  |  AZD9496  |  Zearalenone  |  Saikosaponin D  |  Giredestrant  |  Chrysin  |  Bazedoxifene

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds