DS45500853,2735803-28-6

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DS45500853

CAS No. : 2735803-28-6

MCE 国际站：DS45500853

产品活性：DS45500853 是一种雌激素相关受体 α (ERRα) 激动剂。DS45500853 抑制受体相互作用蛋白 140 (RIP140) 辅助阻遏肽 (10 nM) 和 GST-ERRα 配体结合结构域 (LBD; 1.2 μM) 之间的结合，IC₅₀ 值为 0.80 μM。DS45500853 可用于代谢紊乱研究，如 2 型糖尿病。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：Estrogen Receptor/ERR

In Vitro: DS45500853 (compound 5c; 0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL; 18 h) activates the transcriptional activity of full-length ERRα in MG63 cells with an EC₅₀ of 5.4 μM.
DS45500853 binds in the ligand-binding pocket (LBP) of the ERRα LBD as inverse agonist II.

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