SD-1029,118372-34-2

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SD-1029

CAS No. : 118372-34-2

MCE 国际站：SD-1029

产品活性：SD-1029 是一种 JAK2/STAT3 抑制剂。SD-1029 抑制 STAT3 核易位。SD-1029 抑制 JAK2 磷酸化，从而抑制 STAT3 激活。

研究领域：Epigenetics  |  Protein Tyrosine Kinase/RTK  |  JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶点：JAK  |  STAT

In Vitro: SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells.
SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8_TR ovarian cancer cells.
SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines.
SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression.

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