D-Cl-amidine,2985338-61-0

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D-Cl-amidine hydrochloride

CAS No. :

MCE 国际站：D-Cl-amidine hydrochloride

产品活性：D-Cl-amidine hydrochloride是有效的、高度选择性的 PAD1 抑制剂。D-Cl-amidine 耐受性好、无明显毒性。

研究领域：Epigenetics  |  Apoptosis

作用靶点：Protein Arginine Deiminase  |  Apoptosis

In Vitro: D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells.
?D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis.

In Vivo: D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ～10 nM at 4 h when administered by ip at a dose of 10 mg/kg.

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