- 询价
- Cell Signaling Technology
- 4002
- USA
- 2025年08月15日
- W
- Rabbit
- M,H,R,Pg
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Troponin I Antibody
- 抗原：
two synthetic peptides corresponding to the sequence of human troponin I
- 应用范围：
W
- 宿主：
Rabbit
- 适应物种：
M,H,R,Pg
- 供应商：
CST
- 保质期：
详见说明书
- 库存：
大量
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | M (H) (R) (Pg) | Endogenous | 28 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Troponin I Antibody detects endogenous levels of total troponin I, both skeletal muscle and cardiac isoforms. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with two synthetic peptides corresponding to the sequence of human troponin I. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from unstimulated and isoproterenol stimulated myocytes, using Troponin I Antibody. Western Blotting
Western blot analysis of extracts from human heart tissue using Troponin I Antibody. |
| Background | Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+ -binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI) (1). In response to β-adrenergic stimulation of the heart, Ser23 and Ser24 of TnI (cardiac) are phosphorylated by PKA and PKC. This phosphorylation stimulates a conformational change of the regulatory domain of TnC, reduces the association between TnI and TnC, and decreases myofilament Ca2+ sensitivity by reducing the Ca2+ binding affinity of TnC (1-3). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Optimization of Cardiac Troponin I Pull-Down by Idm Affinity Beads and SELDI-TOF
Cardiac troponin I (cTnI) is a key regulator of cardiac muscle contraction. Upon myocardial cell injury, cTnI is lost from the cardiac myocyte and can be detected in serum, in some cases with specific disease-induced modifications, making
大鼠肌钙蛋白I(Troponin I)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 大鼠肌钙蛋白 I(Troponin I)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗大鼠 Troponin I 单抗包被于酶标板上，标准品和样品中的 Troponin I 与单抗结合，加入生物素化的抗大
-rich region] of the rat cardiac troponin T promoter. In GMSA, the specificity of the binding of trans-acting factor to labeled DNA probe should be verified by the addition of unlabeled probe in the reaction mixture. The migratory property of DNA-protein
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