- 询价
- Cell Signaling Technology
- 4942
- USA
- 2026年05月28日
- W, IHC-P
- Rabbit
- H,M,R
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- 询价记录
- 技术资料
- 抗体英文名：
PBK/TOPK Antibody
- 抗原：
synthetic peptide corresponding to amino acids at the carboxy-terminus of human PBK/TOPK
- 应用范围：
W, IHC-P
- 宿主：
Rabbit
- 级别：
详见MSDS文件
- 适应物种：
H,M,R
- 库存：
大量
- 保质期：
详见说明书
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IHC-P | H M R | Endogenous | 40 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | PBK/TOPK Antibody detects endogenous levels of total PBK/TOPK protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids at the carboxy-terminus of human PBK/TOPK. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from NIH/3T3 and PC12 cells, using PBK/TOPK Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, showing membrane and cytoplasmic localization, using PBK/TOPK Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using PBK/TOPK Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded ME-180 cells, using PBK/TOPK Antibody (left), or no primary antibody (right). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using PBK/TOPK Antibody preincubated with an irrelevant control peptide (left) or antigen specific peptide (right). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using PBK/TOPK Antibody. |
| Background | PBK/TOPK is a serine/threonine kinase that is phosphorylated and active during mitosis (1). PBK/TOPK is composed of kinase subdomains and a carboxy-terminal PDZ-Binding domain, which is thought to interact with the tumor suppressor protein hDlg (1). Increased PBK/TOPK expression has been observed in highly proliferative malignant cell lines, and PBK/TOPK expression is strongly downregulated during terminal differentiation of HL-60 leukemic cells (2,3). PMA-induced kinase activity toward PBK/TOPK has been observed (4), and cdc2/cyclinB has been shown to phosphorylate PBK/TOPK in vitro, presumably at Thr9 (1). Potential substrates of PBK/TOPK include p38 MAPK and c-Myc (3,4).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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