- 询价
- Cell Signaling Technology
- 4651
- USA
- 2025年10月24日
- W
- Rabbit
- H,M,R,Mk
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- 详细信息
- 询价记录
- 技术资料
- 抗体英文名：
Rac1/Cdc42 Antibody
- 抗原：
synthetic peptide corresponding to residues near the amino termini of human rac1 and cdc42
- 应用范围：
W
- 宿主：
Rabbit
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 供应商：
CST
- 库存：
大量
- 适应物种：
H,M,R,Mk
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R Mk | Endogenous | 21 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Rac1/Cdc42 Antibody recognizes endogenous levels of total rac1 and cdc42 protein. Based on sequence similarities, the antibody may react with rac2 and rac3. The antibody does not cross-react with rhoA, rhoB or rhoC. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino termini of human rac1 and cdc42. Antibodies are purified using protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of recombinant GST-tagged small GTPases RhoA, RhoB, RhoC, Cdc42 and Rac1 using Rac1/Cdc42 Antibody. Western Blotting
Western blot analysis of extracts from various cell lines using Rac1/Cdc42 Antibody. |
| Background | Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development (1). GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein's intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state (2,3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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