- 询价
- Cell Signaling Technology
- 2760
- USA
- 2025年08月07日
- IHC-P, IHC-F, IF-F
- Rabbit
- H,M,R
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Glucagon Antibody
- 抗原：
synthetic peptide corresponding to the sequence of human glucagon
- 应用范围：
IHC-P, IHC-F, IF-F
- 宿主：
Rabbit
- 库存：
大量
- 级别：
详见MSDS文件
- 适应物种：
H,M,R
- 供应商：
CST
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (100 sections)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (100 sections) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IF-F=Immunofluorescence (Frozen)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| IHC-P IHC-F IF-F | H M R | Endogenous | 4 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Glucagon Antibody detects endogenous levels of total glucagon protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human glucagon. Antibodies are purified by protein A and peptide affinity chromatography. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human pancreas, showing staining of α cells, using Glucagon Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded mouse pancreas, showing staining of α cells, using Glucagon Antibody. IHC-F (frozen)
Immunohistochemical analysis of frozen mouse pancreas using Glucagon Antibody. IF-F
Confocal immunofluorescent analysis of normal mouse pancreas using Glucagon Antibody (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
| Background | Glucose homeostasis is regulated by a variety of hormones including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver (1,2). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验胰高血糖素 glucagon 亦称胰增血糖素或抗胰岛素或胰岛素 B。它是伴随胰岛素由脊椎动物胰脏的胰岛α细胞分泌的一种激素。与胰岛素相对抗，起着增加血糖的作用。于 1953年，被分离沉淀而取得结晶。它是以 N-末端组氨酸为起点， C末端苏氨酸为终点的 29个氨基酸残基组成的一条单链肽（分子量约为 3500），分子内不具有 S-S键，在这一点上，完全不同于胰岛素。该化合物的结构已由最近的化学合成所肯定。胰高血糖素的作用初期过程是与存在于靶细胞细胞膜上的受体进行特异性结合，将腺苷
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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