- 询价
- Cell Signaling Technology
- 2504
- USA
- 2025年08月17日
- W, IP
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
APC Antibody
- 抗原：
synthetic peptide corresponding to the sequence of human APC
- 应用范围：
W, IP
- 宿主：
Rabbit
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 库存：
大量
- 供应商：
CST
- 适应物种：
H,M,R,Mk
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H (M) (R) (Mk) | Endogenous | 160 truncated APC in SW480 cells. 310 full-length APC. | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | APC Antibody detects endogenous levels of total APC protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human APC. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis (lane 1) and Immunoprecipitation (lanes 2-3) of extracts from SW480 cells. APC was immunoprecipitated with APC Antibody (lane 2) or with rabbit IgG (lane 3) to confirm specificity. Western blot was detection was performed using APC Antibody. |
| Background | The Adenomatous Polyposis Coli (APC) tumor suppressor gene is mutated in most familial and sporadic colorectal cancers and encodes a large cytoplasmic protein that is implicated in cell migration, cell adhesion, and proliferation (1). APC binds directly to microtubules and lack of APC leads to defective mitotic spindles and aneuploidy due to missegregation of chromosomes (2). APC is well characterized as a scaffolding protein, binds to β-catenin, and is involved in the regulation of its intracellular concentration. In the absence of a Wnt signal, GSK-3β phosphorylates all three members of the APC-β-catenin-axin complex and this phosphorylation of β-catenin creates a recognition site for ubiquitin, the signal for proteasome-mediated degradation. In the presence of a Wnt signal, dishevelled inactivates GSK-3β and β-catenin coordinates gene transcription of proteins important for the control of cell cycle progression and proliferation, such as cyclin D1 and c-Myc (3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验酶活性的DNA聚合酶，原来通常使用的是Taq DNA聚合酶，缺少校正功能。在这儿我们展示将长PCR技术应用到5＇RACE系统中，来分离5.5kb长的人结节性脑硬化II（tuberous sclerosis II，TSC-2）mRNA和8.9kb长的腺瘤性结肠息肉（adenomatous polyposis coli，APC）mRNA的5＇末端，扩增的5＇末端片段要比单独用Taq DNA聚合酶获得的片段长。方法使用5＇RACE系统版本2 （Cat. No. 18374-058）来扩增TSC-2和APC
APC 由阿斯匹林（ Aspirin ）、非那西汀（ Phenacetin ）与咖啡因（ Caffeine ）组成。它有三个主要的生理功能：止痛、退热降温和消炎（如活动性风湿症、类风湿性关节炎）。阿斯匹林的化学名为乙酰水杨酸，由水杨酸（即邻羟基苯甲酸）与醋酐反应而制得： 其实，水杨酸本身已具有上述生理功能，但酚基会刺激人的嘴和咽喉。在水杨酸分子中— OH 被转变为 基，便消除了水杨酸的副作用。服用后进入消化系统，它又转变成水杨
非专职 APC 一类各自具有特定功能，诱导后可参与提呈抗原的细胞。在通常条件下，这类细胞执行其功能而不表达MHCⅡ类分子，因而不具备提呈抗原的能力。但在细胞因子和病原体的作用下，特别在炎症反应持续的阶段中，可被诱导而表达为抗原提呈所必需的MHCⅡ类分子和共信号分子，以非专职形式行使抗原提呈功能。属于非专职APC的，有血管内皮细胞、皮肤成纤维细胞、皮肤角质形成细胞、胸腺上皮细胞、甲状腺上皮细胞、胰岛β细胞、脑小胶质细胞等。 血管
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