Octahydrocurcumin

具有多种生物活性的姜黄素活性代谢物；在无细胞测定中清除DPPH自由基(IC50=12.3µM)；在6.25µM浓度下抑制RAW 264.7细胞中LPS诱导的iNOS和COX-2水平升高、NO产生和NF-ᴋB核易位；在盘状测定中对抗各种细菌和真菌；在5、10和20mg/kg浓度下增加H22鼠肝细胞癌模型的存活率、降低肿瘤重量并诱导肿瘤细胞凋亡。An active metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 12.3 µM); inhibits LPS-induced increases in iNOS and COX-2 levels, production of NO, and nuclear translocation of NF-ᴋB in RAW 264.7 cells at 6.25 µM; active against various bacteria and fungi in disc assays; increases survival, reduces tumor weight, and induces tumor cell apoptosis in an H22 murine hepatocellular carcinoma model at 5, 10, and 20 mg/kg.分子式C21H28O6分子量376.4OC1=C(OC)C=C(CCC(O)CC(O)CCC2=CC(OC)=C(O)C=C2)C=C1