UPF-648

Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteins

A method was developed to assess the functional significance of a sequence motif in yeast Upf3p, a protein required for nonsense-mediated mRNA decay (NMD). The motif lies at the edge of the Upf3p-Upf2p interaction domain, but at the same time

识别和表征加速降解包含早期翻译终止密码子的mRNAs的基因

摘要 In both prokaryotes and eukaryotes nonsense mutations in a gene can enhance the decay rate of the mRNA transcribed from that gene, a phenomenon described as nonsense-mediated mRNA decay. In yeast, the products of the UPF1 and UPF3 genes

4.10 科研早报：《Nature》4月最受关注的五篇论文

一些我们以前从未知晓的生物学机理。”研究人员希望进一步研究corallicolid，了解它们的生活习性，从而更好的保护它们。第五篇：PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components生命中的遗传物质脱氧核糖核酸（DNA）时时刻刻都会受到损伤的威胁，每个细胞的基因组DNA每天会遇到约10000次的损伤。这些损伤导致的基因变异会使编码蛋白的基因失去功能，进而影响生命的意义。为了存活