Phenprocoumon

一种抗凝剂和维生素K拮抗剂；在基于细胞的报告试验中抑制野生型VKOR（IC50=4.2nM）以及多种突变型VKOR（IC50=5.1-835nM）的活性；以剂量依赖性方式抑制大鼠的凝血酶原复合物合成。An anticoagulant and vitamin K antagonist; inhibits the activity of wild-type VKOR (IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays; inhibits prothrombin complex synthesis in rats in a dose-dependent manner.分子式C18H16O3分子量280.3O=C1OC2=C(C(O)=C1C(CC)C3=CC=CC=C3)C=CC=C2