Coumarin-Quinone Conjugate

香豆素 coumarin

　　香豆素 coumarin 将含有香豆素基本结构的化合物总称为香豆素（类）。是邻阔马酸的内酯，几乎所有香豆素在 7位炭上都有羟基，其它位置也常被甲氧基和烷基等所置换。也有具有类异戊二烯等复杂侧链的，具有呋喃环（呋喃香豆素）或吡喃环（吡喃香豆素）的。简单的香豆素有伞形酮、七叶亭、莨菪亭等，以糖苷的形式存在于许多植物中，特别是菊科、豆科、伞形科和禾本科中。具有复杂结构的可在伞形科、芸香科和豆科植物中见到。因有特殊香味，除用于制作香料外，还具有药理作用，例如有的可利用其毒性而以制作杀鼠

Polysaccharicb-Conjugate Vaccines

It was recognized early this century that small molecules, called haptens, can be made immunogenic after conjugation to carrier proteins (1 ), This principle was thereafter applied successfully to improve the rmmunogenicity of (poly

AntibodyDrug Conjugate Payloads

Toxin payloads, or drugs, are the crucial components of therapeutic antibody–drug conjugates (ADCs). This review will give an introduction on the requirements that make a toxic compound suitable to be used in an antitumoral ADC