H-Val-Pro-Pro-OH (trifluoroact

肽ACE抑制剂(IC50=9µM)；1µM时抑制HUVEC中乙酰胆碱诱导的NO生成；诱导预收缩的大鼠主动脉环中的血管舒张；0.3mg/kg时降低自发性高血压大鼠的收缩压；饮食管理可降低ApoE-/-小鼠的血浆总胆固醇、HDL-胆固醇和甘油三酯水平、Il6和Il1b表达、主动脉弓内膜增厚和动脉粥样硬化斑块形成。A peptide ACE inhibitor (IC50 = 9 µM); inhibits acetylcholine-induced NO production in HUVECs at 1 µM; induces vasorelaxation in precontracted isolated rat aortic rings; decreases systolic blood pressure in spontaneously hypertensive rats at 0.3 mg/kg; dietary administration reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, expression of Il6 and Il1b, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE-/- mice.