BAY 87-2243

线粒体复合物I抑制剂和铁死亡诱导剂；降低H1299luc细胞中ATP依赖性荧光素酶报告基因活性和ATP水平；诱导ROS产生，增加α-生育酚敏感的脂质过氧化，并降低SK-MEL-28和G361黑色素瘤细胞中的GSH水平；降低H460小鼠异种移植模型中的肿瘤重量、HIF-1α水平和HIF-1α靶基因表达（0.5-4mg/kg）；减缓MEXF276和MEXF1732黑色素瘤PDX小鼠模型中的肿瘤生长。A mitochondrial complex I inhibitor and inducer of ferroptosis; decreases ATP-dependent luciferase reporter activity and ATP levels in H1299luc cells; induces production of ROS, increases α-tocopherol-sensitive lipid peroxidation, and decreases GSH levels in SK-MEL-28 and G361 melanoma cells; reduces tumor weight, HIF-1α levels, and HIF-1α target gene expression in an H460 mouse xenograft model from 0.5-4 mg/kg; reduces tumor growth in the MEXF 276 and MEXF 1732 melanoma PDX mouse models.