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- Cell Signaling Technology
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- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
VEGF Receptor 3 (C28G5) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Gly990 of human VEGF Receptor 3
- 应用范围：
W
- 级别：
详见MSDS文件
- 供应商：
CST
- 库存：
大量
- 保质期：
详见说明书
- 适应物种：
H
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W | H | Transfected Only | 195 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | VEGF Receptor 3 (C28G5) Rabbit mAb detects transfected levels of VEGFR3. This antibody does not cross-react with other family members. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly990 of human VEGF Receptor 3. Western Blotting
Western blot analysis of extracts from COS cells transfected with human VEGFR3 expression constructs (right) and mock transfected COS cells (left) using VEGF Receptor 3 (C28G5) Rabbit mAb. |
| Background | Vascular endothelial growth factor receptor 3 (VEGFR3) is a 195 kDa membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig)-like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain (1). VEGF receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis (1,2). Binding of VEGF-C/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1/2 and Akt signaling cascades (1,3). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验h）即可。2. 修复大法——不仅仅是「煮一煮」微波炉修复：简单易行效果好，CST 推荐使用微波炉完成修复。合适的修复液：根据抗体说明书使用合适的修复液。用柠檬酸修复后，切片需浸泡在修复液中，自然冷却；而用 EDTA 修复后，切片可直接从修复缸中取出，直接进行下一步。注：使用不同的修复方式和不同生产商的抗体检测人肺癌组织中 EGFR 的表达。第一排为 CST 的 EGF Receptor (D38B1) XP® Rabbit mAb（#4267），EDTA 的修复方式明显优于柠檬酸盐及胃蛋白
【翻译】Development trends for monoclonal antibody cancer therapeutics
7 and patients frequently developed antibodies to the mouse-derived proteins, which limited their utility8, 9. In addition, only certain murine mAb isotypes have been shown to effectively bind to and activate elements of the human immune
本文已发表于中国肿瘤生物治疗杂志．2003，10（3）：221-222．【摘要】表皮生长因子受体（Epidermal Growth Factor Receptor EGFR）是原癌基因ｃ-erb-B1的表达产物。其过表达和突变体均与肿瘤发生发展有密切关系，基于此优点成为目前肿瘤治疗的新靶点。本文就EGFR与肿瘤的关系及其单抗治疗肿瘤的进展作一综述。【关键词】表皮生长因子受体（EGFR），单克隆抗体，肿瘤治疗【中图分类号】R730.5 ［文献标识码］ AEGFR monocolonal
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