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Collagenase
2-5年
上海曼博生物医药科技有限公司
2°C~ 8 °C
1g
人 | 猪 | 啮齿动物 | 其他 |
脂肪 | 肝脏 | 皮肤 |
骨 | 肺 | 甲状腺 |
软骨 | 肌肉 | 肿瘤 |
结肠 | 神经 | 脐带 |
胃/肠 | 胰腺 | 心脏 |
生殖系统 |
腺泡细胞 | 上皮细胞 | 肌肉细胞 |
脂肪细胞 | 成纤维细胞 | 神经元 |
羊膜细胞 | 肝细胞 | 卵母细胞 |
心肌细胞 | 胰岛 | 成骨细胞 |
软骨细胞 | 白细胞 | 雪旺细胞 |
绒毛膜细胞 | 肺细胞 | 干细胞 |
子宫内膜细胞 | 肥大细胞 | 肿瘤细胞 |
内皮细胞 | 黑色素瘤细胞 |
品名 | 胶原酶活性 | 蛋白水解副作用 |
Collagenase NB 4 Standard Grade | + | ++ |
Collagenase NB 5 Sterile Grade | ||
Collagenase NB 6 GMP Grade | ||
Collagenase NB 4G Proved Grade | ++ | +++ |
Collagenase NB 7D Gentle Grade | ++ | + |
Collagenase NB 8 Broad Range | +++ | + |
Collagenase NB 1 Premium Grade | ++++ | - |
Collagenase NB 1 GMP Grade | ||
Collagenase AF-1 GMP Grade |
Title | Reference | Cell Type |
Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis | Sendler, M. et al. J. Biol. Chem. 2016, 291, 14717-14731. | Acinar cells |
Signaling pathways involved in LPS induced TNFalpha production in human adipocytes | Hoareau, L. et al. Journal Inflamm.2010, 7. | Adipocytes |
Ceiling Culture-Derived Proliferative Adipocytes are A Possible Delivery Vehicle for Enzyme Replacement Therapy in Lecithin: Cholesterol Acyltransferase Deficiency | Kuroda, M. et al. Open Gene Ther. J. 2011, 4, 1-10. | Adipocytes |
Autologous fat transfer with in-situ mediation AIM a novel and compliant method of adult mesenchymal stem cell therapy | Wu, A. Y. and Morrow, D. J. Translat. Med. 2013, 11. | Adipose stem cells (ASC) |
Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells | Patrikoski, M. et al. Stem Cell Res Ther. 2013, 4, 27. | Adipose stem cells (ASC) |
Xenofree Enzymatic Products for the Isolation of Human Adipose-Derived Stromal/Stem Cells | Carvalho,P. et al. Tiss Eng Part C Methods 2013, 19. | Adipose stem cells (ASC) |
Human Adipose-Derived Mesenchymal Stem Cells in Cell Therapy: Safety and Feasibility in Different "Hospital Exemption" Clinical Applications | Veriter, S. et al. Plos One 2015, 10, e0139566. | Adipose stem cells (ASC) |
A Standardized Method of Isolating Adipose-Derived Stem Cells for Clinical Applications | Raposio, E. et al. Annals Plast. Surg. 2015, 00. | Adipose stem cells (ASC) |
Use of Bioengineered Bone for Sinus Augmentation | Beaumont, C. et al. J Periodontol 2008, 79, 541-548. | Bone |
A nonaggressive, highly efficient, enzymatic method for dissociation of human braintumors and braintissues to viable singlecells | Volovitz, I. et al. BMC Neurosci. 2016, 17, 1-10. | Brain Cells |
Cerebral endothelial cells release TNF-alpha after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops | Freyer, D. et al. J. Immunol. 1999, 163, 4308-4314. | Cerebral endothelial cells |
Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones | Schroeder, N. et al. Plos One 2019, 14, e0218230. | Chondrozytes |
Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo | Finotto,S. et al. Gut 2004, 53, 392-400. | Hepatocytes |
Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo | Aurich, H. et al. Gut 2009, 58, 570-581. | Hepatocytes |
Cold Storage of Rat Hepatocyte Suspensions for One Week in a Customized Cold Storage Solution – Preservation of Cell Attachment and Metabolism | Pless-Petig, G. et al. PlosOne 2012, 7, e40444. | Hepatocytes |
Comparison of methods for isolating primary hepatocytes from mini pigs | Li, Y. et al. Xenotransplantation2016, 0, 1-7. | Hepatocytes |
Good manufacturing practice and clinical-grade human embryonic stem cell lines | Unger, C.Human Mol. Gen. 2008, 17, R48-R53. | Human embryonic stem cells (hESC) |
Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies | Hentze, H. et al. Stem Cell Res. 2009, 2, 198-210. | Human embryonic stem cells (hESC) |
Intrahepatic Administration of Human Liver Stem Cells in Infants with Inherited Neonatal-Onset Hyperammonemia: A Phase I Study | Spada, M. et al. Stem Cell Rev Rep. 2020, 16, 186-197. | Human Liver Stem Cells (HLSC) |
Cryopreservation of human vascular umbilical cord cells under good manufacturing practice conditions for future cell banks | Polchow, B. et al. J Transl Med. 2012, 10, 98. | Human umbilical vein endothelial cells (HUVEC) |
Successful Single Donor Islet Allotransplantation in the Streptozotocin Diabetes Rat Model | Jahr, H. Cell Transplant. 2002, 11, 513-518. | Islets of Langerhans |
Tyrosine hydroxylase activity in the endocrine pancreas: changes induced by short-term dietary manipulation | Borelli, M. I. et al. BMC Endocr Disord. 2003, 3. | Islets of Langerhans |
Influence of Collagenase Loading on Long-Term Preservation of Pig Pancreas by the Two-Layer Method for Subsequent Islet Isolation | Brandhorst, D. et al. Transplant. 2005, 79,38-43. | Islets of Langerhans |
Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia. | Brandhorst, D. et al. Xenotransplant. 2006, 13, 465-470. | Islets of Langerhans |
Current status of pancreatic islet transplantation | Merani, S. and Shaprio, A. M. J. Clin Sci (Lond.) 2006, 110, 611-625. | Islets of Langerhans |
Quantification of Basal and Stimulated ROS Levels as Predictors of Islet Potency and Function | Armann, B et al. Am J Transplant. 2007, 7,38-47. | Islets of Langerhans |
Factors Influencing the Collagenase Digestion Phase of Human Islet Isolation | Kin, T. et al. Transplant.2007, 83, 7-12. | Islets of Langerhans |
Improvement of pancreatic islet cell isolation for transplantation | Matsumoto,S. et al. Proc (Bayl Univ Med Cent.) 2007, 20, 357-562. | Islets of Langerhans |
Collagenase penetrates human pancreatic islets following standard intraductal administration | Cross, S.E. Transplant. 2008, 86, 907-911. | Islets of Langerhans |
Iodixanol-Controlled Density Gradient During Islet Purification Improves Recovery Rate in Human Islet Isolation | Noguchi, H. et al. Transplant. 2009, 87, 1629-1635. | Islets of Langerhans |
Pig Pancreas Oxygenation at 20°C Increases Islet ATP Generation but Deteriorates Islet Function | Iken, m. et al. Cell Transplant. 2009, 18, 745-751. | Islets of Langerhans |
The Importance of Tryptic-like Activity in Purified Enzyme Blends for Efficient Islet Isolation | Brandhorst, H. et al. Transplant. 2009, 87, 370-375. | Islets of Langerhans |
Human Islet Isolation for Autologous Transplantation: Comparison of Yield and Function Using SERVA/Nordmark Versus Roche Enzymes | Anazawa,T. et al. Am J Transplant. 2009, 9, 2383-2391. | Islets of Langerhans |
Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue | Qi, M. J Vis Exp. 2009, 26, 1125-1126. | Islets of Langerhans |
Low-Temperature Preservation of Isolated Islets is Superior to Conventional Islet Culture Before Islet Transplantation | Noguchi, H. et al. Transplant. 2010, 89, 47-54. | Islets of Langerhans |
Experience of islet isolation without neutral protease supplementation | Kin, T. et al. Islets, 2010, 2, 278-282. | Islets of Langerhans |
Islet Isolation for Clinical Transplantation | Kin, T. Adv Exp Med Biol. 2010, 654, 683-710. | Islets of Langerhans |
A Novel Device for Islte Transplantation Providing Immune Protection and Oxygen Supply | Ludwig, B. et al.Horm Metab Res. 2010, 42, 918-922. | Islets of Langerhans |
Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets | Ludwig, B. et al. PNAS 2010, 107, 12623-12628. | Islets of Langerhans |
Assessment of human islet isolation with four different collagenases | Shimoda,M. et al. Transplant Proc. 2010, 42, 2049-2051. | Islets of Langerhans |
Seven consecutive successful clinical islet isolations with pancreatic ductal injection | Matsumoto, S. et al. Cell Transplant. 2010, 19, 291-297. | Islets of Langerhans |
Large-scale Comparison of Libearse HI and Collagenase NB 1 utilized for Himan Islet Isolation | Brandhorst,H. et al. Cell Transplant. 2010, 19, 3-8. | Islets of Langerhans |
A Simplified Approach to Human Islet Quality Assessment | Hanson, M. S. et al. Transplant. 2010, 89, 1178-1188. | Islets of Langerhans |
Evolution of β-Cell Replacement Therapy in DiabetesMellitus: Islet Cell Transplantation | Jahansouz, C. et al. Diabetes Technol Ther. 2011, 13, 395-418. | Islets of Langerhans |
Recent progress in pancreatic islet transplantation | Kuise, t. and Noguchi, H. World J Transplant. 2011, 1, 13-18. | Islets of Langerhans |
Impact of the number of infusions on 2-year results of islet-after-kidney transplantation in the GRAGIL network | Borot,S et al. Transplant. 2011, 92, 1031-1038. | Islets of Langerhans |
Improved Pancreatic Islet Isolation Outcome in Autologous Transplantation for Chronic Pancreatitis | Naziruddin, B. et al Cell Transplant 2012, 21, 553-558. | Islets of Langerhans |
Comparative impact on islet isolation and transplant outcome of the preservation solutions Institut Georges Lopez-1, University of Wisconsin, and Celsior | Niclauss, N. et al. Transplant. 2012, 93, 703-708. | Islets of Langerhans |
Fresh Islets Are More Effective for Islet Transplantation Than Cultured Islets | Noguchi, H. et al. Cell Transplant. 2012, 21, 517-523. | Islets of Langerhans |
Evaluation of Osmolality of Density Gradient for Human Islet Purification | Noguchi, H. et al. Cell Transplant. 2012, 21, 493-500. | Islets of Langerhans |
Impact of Tissue Volume and Purification on Clinical Autologous Islet Transplantation for the Treatment of Chronic Pancreatitis | Matsumoto,S. et al. Cell Transplant. 2012, 21, 625-632. | Islets of Langerhans |
Update on Islet Transplantation | McCall, M. and Shapiro, A. M. J. Cold Spring Harb Perspect Med. 2012, 2, a007823. | Islets of Langerhans |
Improvement of collagenase distribution with the ductal preservation for human islet isolation | Shimoda, M. et al. Islets 2012, 4, 130-137. | Islets of Langerhans |
Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis | Bottino,R et al. J Transplant. 2012, 642787. | Islets of Langerhans |
Collagenase Does Not Persist in Human Islets Following Isolation | Cross, S. E. Cell Transplant. 2012, 21, 2531-2535. | Islets of Langerhans |
Transplanted Functional Islet Mass: Donor, Islet Preparation, and Recipient Factors Influence Early Graft Function in Islet-After-Kidney Patients | Friberg, A. S. et al. Transplant. 2012, 93, 632-638. | Islets of Langerhans |
Robot-assisted pancreatoduodenectomy with preservation of the vascular supply for autologous islet cell isolation and transplantation: a case report | Giulianotti, P. et al J Med case rep. 2012, 6. | Islets of Langerhans |
Quality of Isolated Pig Islets Is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model | Brandhorst, H. et al. Cell Transplant. 2013, 22, 1477-1483. | Islets of Langerhans |
Clinical islet isolation outcomes with a highly purified neutral protease for pancreas dissociation | O'Gorman, D. et al. Islets, 2013, 5, 111-115. | Islets of Langerhans |
Transplantation of Encapsulated Pancreatic Islets as a Treatment for Patients with Type 1 Diabetes Mellitus | Qi, M. Adv Med. 2014, 429710. | Islets of Langerhans |
Human islet cell isolation: the initial step in an islet transplanting program in Shiraz, Southern Iran | Azarpira,N. et al. Exp Clin Transplant.2014, 12, 139-142. | Islets of Langerhans |
Effects of Donor-, Pancreas-, and Isolation-Related Variables on Human Islet Isolation Outcome: A Systematic Review | Hilling, D. et al. Cell Transplant. 2014, 23, 921-928. | Islets of Langerhans |
Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010 | Balamurugan, A.N. et al. Am J Transplant 2014, 14, 2595-2606. | Islets of Langerhans |
Autologous Islet Transplantation With Remote Islet Isolation After Pancreas Resection for Chronic Pancreatitis | Tai, D.S. et al. JAMA Surg. 2015, 150, 118-124. | Islets of Langerhans |
National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities | Ricordi, C. et al. Diabetes 2016, 65, 3418-3428. | Islets of Langerhans |
Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation? | Brandhorst, D. et al. Rev Diabet Stud, 2016, 14, 22-38. | Islets of Langerhans |
Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity | Brandhorst, H. et al. Cell Transplant 2017, 26, 1733-1741. | Islets of Langerhans |
Evaluation of collagenase gold plus BP protease in isolating islets from human pancreata | Khiatah, B. Islets 2018, 4, 51-59. | Islets of Langerhans |
Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation | Loganathan, G. et al. OBM Transplantation 2019, 3. | Islets of Langerhans |
Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System |
Keshtkar, S. et al. StemCell Int. 2020. | Islets of Langerhans |
Comparison of islet isolation result and clinical applicability according to GMP-grade collagenase enzyme blend in adult porcine islet isolation and culture | Kwak, K. et al. Xenotransplant. 2021, e12703. | Islets of Langerhans |
Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo | Aurich, H. et al. Gut 2009, 58, 570-581. | Mesenchymal Stem Cells |
Nonexpanded mesenchymal stem cells for regenerative medicine - yield in stromal vascular fraction from adipose-tissue | Faustini, M. et al. Tissue Engin. 2010, 16, 1515-1521. | Mesenchymal Stem Cells |
A new standardized clinical-grade protocol for banking human umbilical cord tissue cells | Fazzina, R. et al. Transfusion 2015, 00, 1-10. | Mesenchymal Stem Cells |
Efficient animal-serum free 3D cultivation method for adult human neural crest-derived stem cell therapeutics | Greiner, J. et al. Eur. Cells Mat. 2011, 22, 403-419. | Neural crest-derived stem cells |
Culture bag systems for clinical applications of adult human neural crest-derived stem cells | Greiner, J. et al. Stem Cell Res Ther. 2014, 5, 34. | Neural crest-derived stem cells |
Efficient Schwann cell purification by differential cell detachment using multiplex collagenase treatment | Jin,Y-Q. et al. J Neurosci Methods 2008, 170, 140-148. | Schwann Cells |
The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration | Egana, J. T. et al. Biomterials 2009, 30, 5918-5926. | Stem cells |
Glandular Stem Cells: A New Source for Myocardial Repair? | Guldner, N. W. et al. Chapter in Reg. Medicine and Tiss. Eng. - Cells and Biomat. 2011 | Stem cells |
Cellular modulation of polymeric device surfaces - promise of adult stem cells for neuro-prosthetics | Richter, A. et al. Front Neurosci. 2011, 5, 1-10. | Stem cells |
Validation of an Automated Procedure to Isolate Human Adipose Tissue–Derived Cells by Using the Sepax Technology | Güven, S. et al. Tissue Engin. 2012, 18, 575-582. | Stromal Vascular Fraction |
Development and Validation of a Fully GMP-Compliant Process for Manufacturing Stromal Vascular Fraction - A Cost-Effective Alternative to Automated Methods | Francois, P.Cells 2020, 9, 2158-2182. | Stromal Vascular Fraction |
Pluripotency of adult stem cells derived from human and rat pancreas | Kruse,C. et al. Appl Phys.A 2004 | Pancreatic stellate-like cells (PSLCs) |
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized | Quintana, E. et al. Cancer Cell 2010, 5, 510-523. | Tumor cells |
A nonaggressive, highly efficient, enzymatic method for dissociation of human braintumors and braintissues to viable singlecells | Volovitz, I. et al. BMC Neurosci. 2016, 17,1-10. | Tumor cells |
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资料下载:
Translational_Collagenase_NB-Translational Collagenase NB.pdf 附件下载 (下载 4 次)
Adipocytes_human_NB6-Isolation of Human Adipocytes and ADSC with Collagenase NB 6 GMP Grade.pdf 附件下载 (下载 3 次)
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