- 询价
- 近岸蛋白(Novoprotein)
- CR90
- 中国
- 2025年11月23日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human cGAS
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | 询价 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | 询价 |
| 规格： | 500ug | 产品价格： | 询价 |
| 规格： | 1mg | 产品价格： | 询价 |
Recombinant Human cGAS (CR90)
NOTE: This product is still in the pre-production stage. If you are interested in this product, please contact us directly. We will speed up our production process according to your needs and reserve products for you.
产品说明(Description)
Recombinant Human Cyclic GMP-AMP synthase by our E.coli expression system and the target gene
encoding Met1-Phe522 is expressed.
Accession #: Q8N884
Known as: CGAS; cGAMP synthase; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; h-cGAS; cGAS; MB21D1; C6orf150
制剂（Formulation）
Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 10% Glycerol, pH 8.0.
质量控制（Quality Control）
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
运输(Shipping)
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存(Storage)
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景（Background）
cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulator of inflammatory and autophagy responses in HD. Ribosome profiling revealed that the cGAS mRNA has high ribosome occupancy at exon 1 and codon-specific pauses at positions 171 (CCG) and 172 (CGT) in HD striatal cells. Cyclic GMP-AMP Synthase Is a cytosolic DNA sensor that activates the type I interferon pathway. cGAS bound to DNA in the cytoplasm and catalyzed cGAMP synthesis. cGAS is required for IFNβ induction by DNA transfection and DNA virus infection. Researches also found that the cGAS-cGAMP-STING pathway was indispensable for host anti-viral immunity.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY
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- 内容
- 询问日期
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