Amylin

Activating the NLRP3 Inflammasome Using the Amyloidogenic Peptide IAPP

an inflammasome complex that ultimately cleaves pro-IL-1β and pro-IL-18 into their mature, secreted forms. Here we describe a protocol by which one type of amyloidogenic peptide, islet amyloid polypeptide (IAPP, otherwise known as amylin) can be prepared and used

三句话读懂一篇 CNS：人造蛋白质药物再获突破；每天喝 2～3 杯咖啡，或降低心脏病风险

团队在 Science 杂志上发表研究论文 A structural basis for amylin receptor phenotype。 该研究克服技术瓶颈，利用冷冻电镜技术，解析了高分辨率的三种亚型胰淀素受体的 6 个结构和 4 个降钙素受体结构，揭示了胰淀素受体与不同配体多肽结合后的激活机制，填补了该药物领域研发的理论空白！ 图 7：来源 Science 8. Science：揭示玉米和水稻趋同进化的遗传基础 民以食为天，保护粮食安全就是保卫生命。 2022 年 3 月

Characterization of CGRP Receptor Binding

ligands. Also, some cell lines fail to express CGRP receptors after extensive passage. CGRP binding assays provide a rapid and easy approach for distinguishing between receptors for CGRP and related peptides such as adrenomedullin and amylin.