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- 详细信息
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 英文名：
PNU 37883A
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
57568-80-6
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥1300.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥2100.0 |
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PNU 37883 hydrochloride
CAS No. : 57568-80-6
MCE 国际站：PNU 37883 hydrochloride
产品活性：PNU 37883 hydrochloride (PNU 37883A) 是一种选择性血管 ATP 敏感钾 (Kir6, KATP) 通道阻滞剂。PNU 37883 hydrochloride 具有利尿作用，特异性结合肾脏和血管平滑肌，而不是大脑或胰腺 β 细胞。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Potassium Channel
In Vitro: In HEK-293 cells stably expressing Kir6.2/SUR1, Kir6.2/SUR2A, Kir6.2/SUR2B or Kir6.1/SUR2B, PNU-37883A inhibits four types of KATP channels, but to different extents. Inhibition of the putative smooth muscle KATP channel types, Kir6.2/SUR2B (IC50 of 15 μM) and Kir6.1/SUR2B (IC50 of 6 μM). PNU-37883A significantly inhibits currents generated by expressing Kir6.2Δ26 alone, with an IC50 of 5 μM, which was significantly increased to 38 μM when Kir6.2Δ26 is expressed with SUR2B.
PNU 37883 (0.1-10 nM) hydrochloride produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings. However, treatment with PNU 37883 (10 nM) hydrochloride alone does not modify the vascular tone.
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