N-Desethyl Sunitinib-d5N-去乙基-舒

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N-Desethyl Sunitinib-d5

CAS No. : 1217247-62-5

MCE 国际站：N-Desethyl Sunitinib-d5

产品活性：N-Desethyl Sunitinib-d₅ 是 N-Desethyl Sunitinib 的氘代物。N-Desethyl Sunitinib (SU-12662) 是 Sunitinib 的代谢物。Sunitinib是有效的，ATP 竞争的 VEGFR，PDGFRβ 和 KIT 抑制剂，能够抑制 VEGFR -1，VEGFR -2，VEGFR -3，PDGFRβ 和 KIT 的活性，K_i 值分别为 2，9，17，8 和 4 nM。

研究领域：Others  |  Metabolic Enzyme/Protease

作用靶点：Isotope-Labeled Compounds  |  Drug Metabolite

In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

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