Fmoc-Trp(Boc)-OH

TRP Channels in the Brain

In the past few years the presence of one or another member of the TRP channel family has been described basically in all tissues studied. Moreover, the pattern of expression and the susceptibility to modulators of each channel subtype

关于boc-氨基酸做成酰氯的疑问

问：看了园子里很多帖，有关氨基酸是否可以做成羧基上的酰氯，有人说fmoc保护的还可以，但是手头就只有boc保护的，于是想了下合成方案，望高手指点，就是在低温下（可能冰水中）boc-氨基酸：socl2=1：1（2：1）条件下，用甲苯作溶剂，三乙胺做傅酸剂缓慢滴加来促使boc-氨基酸做成酰氯，希望大家提提意见，是否可行？谢谢。答：请注意，EDC/DCC等不是催化剂，要加化学计量的，不知道“反应效率有限”是指什么意思。做成酰氯可能不容易实现。如果想进一步探讨，请给出反应的结构式、已经尝试过的条件

TRP Channels in the Genitourinary Tract

Recently, TRP channels have been implicated in numerous pathologies of the genitourinary (GU) tract. TRP channels are differently expressed along the GU tract, and several lines of evidence suggest that they also have different roles