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bcl-x单克隆抗体
- 参考价格： ¥3190.0
- 品 牌： abgent
- 货 号： AJ1084a
- 适应物种： 人,小鼠,大鼠
- 应用范围： 流式细胞技术,免疫组化,免疫印迹
- 克 隆 性： 单克隆
- 抗体类型： 一抗
- 基因id： 598
产品概览
| 背景： | Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis (1). Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2 (2). It has been found that eterodimerization with Bax does not seem to be required for anti-apoptotic activity (3). Since Bcl-xL can form an ion channel in synthetic lipid membranes, there is a strong possibility that this property plays a role in heterodimerization-independent cell survival (4). The Bcl-X(S) isoform promotes apoptosis.REFERENCES1. Boise, L.H. et al. Cell 74(4): 597-608 (1993)2. Sedlak, T.W. et al. PNAS U S A. 92(17): 7834-8 (1995)3. Cheng, E.H. et al. Nature 379(6565): 554-6 (1996)4. Minn, A.J. et al. EMBO. J. 18: 632-643 (1999) |
| 其他名字： | BCL2L1, BCL2L, BCLX, Bcl-2-like protein 1, Apoptosis regulator Bcl-X |
| 克隆名： | E18 |
靶点信息
| 蛋白名： | BCL2L1 |
| 胞内定位： | Isoform Bcl-X(L): Mitochondrion inner membrane (By similarity). Mitochondrion outer membrane (By similarity). Mitochondrion matrix (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49 |
| 同义词： | BCL2L, BCLX |
应用与保存
| 稀释浓度： | FC~~1:50IHC~~1:50~1:100WB~~1:1000~10000 |
| 注意事项： | Bcl-x Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. Boise, L.H. et al. Cell 74(4): 597-608 (1993)2. Sedlak, T.W. et al. PNAS U S A. 92(17): 7834-8 (1995)3. Cheng, E.H. et al. Nature 379(6565): 554-6 (1996)4. Minn, A.J. et al. EMBO. J. 18: 632-643 (1999) |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 主要序列号： | Q07817 |
| 分子量： | 26049 Da |
| 功能： | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. |
| 规格： | 100µl | 价格： | ¥3190.00 |
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