| 背景： | Cholecystokinin B Receptor (CCKBR) also known as the Gastrin Receptor and CCKR2, belongs to the 7-transmembrane domain, G-Protein Coupled Receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides1,2.CCK and gastrin are related linear peptides that occur in different forms but share the last five C-terminal amino acid residues. CCK regulates several nutritional-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestinal transit, while gastrin's main function is the stimulation of gastric acid secretion1,2.Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+ mobilization.CCKBR was originally identified in the brain (and hence its name, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa1,2.Alomone Labs is pleased to offer a highly specific antibody directed against an epitope in the extracellular N-terminus of the mouse CCKBR. Anti-Cholecystokinin B Receptor (extracellular) antibody (#AG1294) can be used in Western blot, indirect flow cytometry and immunohistochemical applications, and recognizes CCKBR from mouse, rat and human samples.REFERENCES1. Noble, F. et al. (1999) Pharmacol. Rev. 51, 745.2. Dufresne, M. et al. (2006) Physiol Rev. 86, 805. |
