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caspase-9单克隆抗体
- 参考价格： ¥3190.0
- 品 牌： abgent
- 货 号： AJ1136b
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫印迹,免疫组化,流式细胞技术
- 克 隆 性： 单克隆
- 抗体类型： 一抗
- 克 隆 名： E84
产品概览
| 背景： | Caspase-9 (ICE-LAP6, Mch-6, Apaf-3) is a member of the cysteine aspartic acid protease, or caspase, family. Pro-Caspase-9 exists as a 46 kDa isomer that is cleaved by apoptotic stimulation, and functions as the major initiator caspase in programmed cell death, or apoptosis (1-4). Upon stimulation, cytochrome c is released from mitochondria, and associates with the Pro-Caspase-9/Apaf 1 complex. This complex in turn activates Pro-Caspase-9 by cleaving it into an active 35 kDa fragment and a small 10 kDa fragment (1,2). Activated Caspase-9 cleaves Caspase-3 as well as poly (ADP-ribose) polymerase (PARP) to initiate a caspase cascade and apoptosis (3,4).REFERENCES1. Kuida, K. et al. Reduced Apoptosis and Cytochrome c2. Li, P. et al. Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell 91: 4793. Duan, H. et al. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271: 167204. Srinivasula, S.M. et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J. Biol. Chem. 271: 27099 |
| 其他名字： | CASP9, MCH6, Caspase-9 subunit p10, Apoptotic protease Mch-6;Apoptotic protease-activating factor 3 |
靶点信息
| 基因id： | 842 |
| 蛋白名： | CASP9 |
| 同义词： | MCH6 |
应用与保存
| 稀释浓度： | WB~~1:500~2000IHC~~1:25FC~~1:50 |
| 注意事项： | Caspase-9 Antibody (Pro) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. Kuida, K. et al. Reduced Apoptosis and Cytochrome c2. Li, P. et al. Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade. Cell 91: 4793. Duan, H. et al. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271: 167204. Srinivasula, S.M. et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J. Biol. Chem. 271: 27099 |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 主要序列号： | P55211 |
| 分子量： | 46281 Da |
| 功能： | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP). |
| 规格： | 100µl | 价格： | ¥3190.00 |
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