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cyclin h单克隆抗体
- 参考价格： ¥3190.0
- 品 牌： abgent
- 货 号： AJ1213a
- 适应物种： 人,小鼠
- 应用范围： 免疫印迹,免疫组化,免疫荧光
- 克 隆 性： 单克隆
- 抗体类型： 一抗
- 胞内定位： Nucleus.
产品概览
| 背景： | Cyclin H, a member of the cyclin family, functions as a regulator of CDK kinases (1). It associates primarily with the kinase CDK7 and ring finger protein MAT1 to form the CDK-activating kinase (CAK) complex. CAK binds and activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation (2). Cyclin H is also a substrate of protein kinase 2, a ubiquitously expressed serine/threonine protein kinase required for cell viability and cell cycle progression (3). In addition, the CAK complex is a component of TFIIH and the RNA polymerase II protein complex (2). It participates in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery (1).REFERENCES1. The NCBI handbook [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotech Info; 2002 Oct. Ch. 17, The RefSeq Project. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174(2009). 3. Bavi P et al. Hum Pathol. 39(6):885-94, 2008. |
| 克隆名： | EPR3929 |
靶点信息
| 基因id： | 902 |
| 蛋白名： | CCNH |
应用与保存
| 稀释浓度： | WB~~1:10000~50000IHC~~1:50~100 |
| 注意事项： | Cyclin H Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. The NCBI handbook [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotech Info; 2002 Oct. Ch. 17, The RefSeq Project. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174(2009). 3. Bavi P et al. Hum Pathol. 39(6):885-94, 2008. |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 主要序列号： | P51946 |
| 分子量： | 37643 Da |
| 功能： | Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| 规格： | 100µl | 价格： | ¥3190.00 |
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