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cytokeratin-8单克隆抗体
- 参考价格： ¥3575.0
- 品 牌： abgent
- 货 号： AJ1230f
- 适应物种： 人,小鼠
- 应用范围： 免疫印迹,免疫组化,免疫荧光
- 克 隆 性： 单克隆
- 修 饰： pS73
- 抗体类型： 一抗
产品概览
| 背景： | Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4).REFERENCES1. Ku, N.O. and M.B. Omary. Identification and mutational analysis of the glycosylation sites of human keratin 18. J Biol Chem. 270: 118202. Kulesh, D.A. and R.G. Oshima. Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells. Mol Cell Biol. 8: 15403. Marceau, N. and A. Loranger. Cytokeratin expression, fibrillar organization and subtle function in liver cells. Biochem. Cell Biol. 73: 6194. Fuchs, E. Keratins and the skin. Annu. Rev. Cell. Dev. Biol. 11: 123 |
| 其他名字： | KRT8, CYK8, Keratin, type II cytoskeletal 8, Keratin-8 |
| 克隆名： | E431-2 |
靶点信息
| 基因id： | 3856 |
| 蛋白名： | KRT8 |
| 胞内定位： | Cytoplasm. Nucleus, nucleoplasm (By similarity). Nucleus matrix (By similarity) |
| 同义词： | CYK8 |
应用与保存
| 稀释浓度： | WB~~1:5000IHC~~1:500 |
| 注意事项： | Cytokeratin-8 Antibody Phospho (pS73) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. Ku, N.O. and M.B. Omary. Identification and mutational analysis of the glycosylation sites of human keratin 18. J Biol Chem. 270: 118202. Kulesh, D.A. and R.G. Oshima. Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells. Mol Cell Biol. 8: 15403. Marceau, N. and A. Loranger. Cytokeratin expression, fibrillar organization and subtle function in liver cells. Biochem. Cell Biol. 73: 6194. Fuchs, E. Keratins and the skin. Annu. Rev. Cell. Dev. Biol. 11: 123 |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 主要序列号： | P05787 |
| 分子量： | 53704 Da |
| 功能： | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| 规格： | 100µl | 价格： | ¥3575.00 |
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