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eif-4e单克隆抗体
- 参考价格： ¥3575.0
- 品 牌： abgent
- 货 号： AJ1255c
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫印迹,免疫组化
- 克 隆 性： 单克隆
- 修 饰： pS209
- 抗体类型： 一抗
产品概览
| 背景： | eIF-4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It exists in two forms: as a free form (25 kDa) and as part of a multi-protein complex eIF-4F (1). eIF-4E appears to be the least abundant of the initiation factors and acts as a rate-limiting step of initiation (2). Since translation is regulated by phosphorylation, eIF-4E phosphorylation at Ser 209 by MAPK signal-integrating kinase 1 (Mnk1) and kinase 2 (Mnk2) may directly regulate the rate of protein synthesis initiation (3). There is also evidence that eIF-4E can function as an oncogene (4-5)REFERENCES1. Rychlik, et al Proc. Nat. Acad. Sci. 84: 945-949, 1987.2. Rhoads, R. E., Joshi-Barve, S., and Rinker-Schaeffer, C.(1993) Prog. Nucleic Acids Res. Mol. Biol.46, 183-2193. Gert C. Scheper, Nick A. Morrice, Miranda Kleijn and Christopher G. Proud Molec. Cell. Biol.; February 2001, p. 743-754, Vol. 21, No. 34. Jone et al. Molec. Cell. Biol. 16: 4754-4764, 1996.5. Wendel et al. Nature 428: 332-337, 2004. |
| 其他名字： | EIF4E, EIF4EL1, EIF4F, Eukaryotic translation initiation factor 4E, mRNA cap-binding protein;eIF-4F 25 kDa subunit |
| 克隆名： | EP2151Y |
靶点信息
| 基因id： | 1977 |
| 蛋白名： | EIF4E |
| 胞内定位： | Cytoplasm, P-body. |
| 同义词： | EIF4EL1, EIF4F |
应用与保存
| 稀释浓度： | WB~~1:1000~2000IHC~~1:100 |
| 注意事项： | eIF-4E Antibody Phospho (pS209) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. Rychlik, et al Proc. Nat. Acad. Sci. 84: 945-949, 1987.2. Rhoads, R. E., Joshi-Barve, S., and Rinker-Schaeffer, C.(1993) Prog. Nucleic Acids Res. Mol. Biol.46, 183-2193. Gert C. Scheper, Nick A. Morrice, Miranda Kleijn and Christopher G. Proud Molec. Cell. Biol.; February 2001, p. 743-754, Vol. 21, No. 34. Jone et al. Molec. Cell. Biol. 16: 4754-4764, 1996.5. Wendel et al. Nature 428: 332-337, 2004. |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 主要序列号： | P06730 |
| 分子量： | 25097 Da |
| 功能： | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| 规格： | 100µl | 价格： | ¥3575.00 |
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