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eif-5a单克隆抗体
- 参考价格： ¥3190.0
- 品 牌： abgent
- 货 号： AJ1256b
- 适应物种： 人,小鼠,大鼠
- 应用范围： 免疫印迹,免疫组化
- 克 隆 性： 单克隆
- 抗体类型： 一抗
- 主要序列号： P63241
产品概览
| 背景： | The human eukaryotic translation initiation factor 5A (eIF-5A) is an 18 kDa protein (1). eIF-5A precursor [(ec-eIF-5A(lys)] is the only cellular protein known to contain a specific lysine residue which is transformed into the unique amino acid hypusine [N-(4-amino-2-hydroxybutyl)-lysine] by a series of post-translational reactions (2). eIF-5A promotes the formation of the first peptide bond during the initial stage of protein synthesis (3).REFERENCES1. Park,M.H., Chung,S.I., Cooper,H.L. and Folk,J.E. (1984) J. Biol. Chem., 259, 45632. Park,M.H., Cooper,H.L. and Folk,J.E. (1982) J. Biol. Chem., 257, 72193. Hershey,J.W.B. (1991) Annu. Rev. Biochem., 60, 717 |
| 其他名字： | EIF5A, Eukaryotic translation initiation factor 5A-1, eIF-4D;Rev-binding factor |
| 克隆名： | EP527Y |
靶点信息
| 基因id： | 1984 |
| 蛋白名： | EIF5A |
| 胞内定位： | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions |
应用与保存
| 稀释浓度： | WB~~1:1000~10000IHC~~1:250~500 |
| 注意事项： | eIF-5A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | 1. Park,M.H., Chung,S.I., Cooper,H.L. and Folk,J.E. (1984) J. Biol. Chem., 259, 45632. Park,M.H., Cooper,H.L. and Folk,J.E. (1982) J. Biol. Chem., 257, 72193. Hershey,J.W.B. (1991) Annu. Rev. Biochem., 60, 717 |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| 分子量： | 16832 Da |
| 功能： | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. |
| 规格： | 100µl | 价格： | ¥3190.00 |
- 相关信息
| 产品名 | 品牌名 |
|---|---|
| eif4e多克隆抗体 | abgent |
| eif-5a单克隆抗体 | abgent |
| eif-4e单克隆抗体 | abgent |
| eif-4e单克隆抗体 | abgent |
| eif-4e单克隆抗体 | abgent |