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抗人emd多克隆抗体
- 参考价格： ¥1100.0 - 2310.0
- 品 牌： abgent
- 货 号： AP6525b
- 适应物种： 人
- 应用范围： 免疫印迹,流式细胞技术
- 克 隆 性： 多克隆
- 亚 型： Rabbit Ig
- 抗体类型： 一抗
- 详细信息
- 图片
详细信息
产品概览
| 背景： | Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.REFERENCESAsioli,S., Histopathology 54 (5), 571-579 (2009)Tilgner,K., J. Cell. Sci. 122 (PT 3), 401-413 (2009) |
| 其他名字： | EMD; EDMD; STA; Emerin |
靶点信息
| 基因id： | 2010 |
| 蛋白名： | EMD |
| 胞内定位： | Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus |
| 同义词： | EDMD, STA |
应用与保存
| 稀释浓度： | WB~~1:1000WB~~1:1000FC~~1:10~50 |
| 注意事项： | EMD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
其他
| 参考文献： | Asioli,S., Histopathology 54 (5), 571-579 (2009)Tilgner,K., J. Cell. Sci. 122 (PT 3), 401-413 (2009) |
| 保存条件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 标记物： | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| 主要序列号： | P50402 |
| 分子量： | 28994 Da |
| 功能： | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. |
| 规格： | 80 µl (8 western blots) | 价格： | ¥1100.00 |
| 规格： | 400 µl (40 western blots) | 价格： | ¥2310.00 |
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Flow cytometric analysis of MDA-231 cells using EMD Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Western blot analysis of EMD antibody (C-term) (Cat.# AP6525b) in MCF-7 cell line lysates (35ug/lane). EMD (arrow) was detected using the purified Pab.
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