p2x1 receptor 抗体_货号：AG1062-丁香通

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p2x1 receptor 抗体

参考价格： ¥4125.0 - 5225.0
品　　牌： abgent
货　　号： AG1062
适应物种：人,小鼠,大鼠
应用范围：免疫印迹,免疫组化,流式细胞技术,免疫细胞化学
抗体类型：一抗
其他名字： P2RX1
基因id： 5023

详细信息
图片

产品概览

背景：

The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP.The structure and function of the P2X receptors, investigated mainly using in vitro models, indicate their involvement in synaptic communication, cell death, and differentiation. Seven mammalian P2X receptor subtypes (P2X1–P2X7) have been identified and cloned1-3. All P2X receptor subtypes share the same structure of intracellular N- and C-termini two membrane-spanning domains and a large extracellular loop. All P2X receptor subtypes can assemble to form homomeric or heteromeric functional channels with the exception of P2X6, which only seems to function as part of a heteromeric complex4-9. The various P2X receptor subtypes show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous systems, while the P2X7 receptor is predominantly found in cells of the immune system4. The P2X1 receptor is present in smooth muscle, cerebellum, dorsal horn spinal neurons, and platelets where it is suggested to play a regulatory role during in vivo homeostasis and thrombosis3,4,10,11.REFERENCESReferences 1. Prasad, M.et al.(2001)J. Physiol.537, 667. 2. Florenzano, F.et al.(2002)Neuroscience115, 425. 3. Ashcroft, F.M.et al.(2000)Ion Channels and DiseaseEd 1, p. 405, Academic Press, San Diego. 4. Khakh, B.S.et al.(2001)Pharmacol. Rev.53, 107. 5. Ding, Y.et al.(2000)J. Auton. Nerv. Syst.81, 289. 6. Lê, K.T.et al.(1998)J. Neurosci.18, 7152. 7. Robertson, S.J.et al.(2001)Curr. Opin. Neurobiol.11, 378. 8. Dunn, P.M.et al.(2001)Prog. Neurobiol.65, 107. 9. Kim, M.et al.(2001)EMBO J.20, 6347. 10. Burnstock, G. (2001)Trends Pharmacol. Sci.22, 182. 11. Oury, C.et al. (2003)Blood101, 3969.

应用与保存

配制：	50 µl or 0.2 ml deionized water, depending on the sample size.
配制前保存条件：	Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
配制前对照抗原保存条件：	Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
配制后保存条件：	The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
配制后对照抗原保存条件：	-20ºC.
配制后抗体浓度：	0.8 mg/ml.
配制后缓冲液：	Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
稀释浓度：	WB~~1:200ICC~~1:50

其他

参考文献：	References 1. Prasad, M.et al.(2001)J. Physiol.537, 667. 2. Florenzano, F.et al.(2002)Neuroscience115, 425. 3. Ashcroft, F.M.et al.(2000)Ion Channels and DiseaseEd 1, p. 405, Academic Press, San Diego. 4. Khakh, B.S.et al.(2001)Pharmacol. Rev.53, 107. 5. Ding, Y.et al.(2000)J. Auton. Nerv. Syst.81, 289. 6. Lê, K.T.et al.(1998)J. Neurosci.18, 7152. 7. Robertson, S.J.et al.(2001)Curr. Opin. Neurobiol.11, 378. 8. Dunn, P.M.et al.(2001)Prog. Neurobiol.65, 107. 9. Kim, M.et al.(2001)EMBO J.20, 6347. 10. Burnstock, G. (2001)Trends Pharmacol. Sci.22, 182. 11. Oury, C.et al. (2003)Blood101, 3969.
对照实验相关产品：	Control peptide antigen (supplied with the antibody free of charge).
对照抗原配制：	100 µl DDW.
标记物：	Affinity purified antibody, lyophilized powder
主要序列号：	P51575
分子量：	44980 Da
同源性：	Rat, mouse - 11/14 amino acid residues identical.
提取：	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
预吸附控制：	1 µg peptide per 1 µg antibody.
验证肽：	Confirmed by mass-spectrography and amino acid analysis.

规格：	0.2 ml	价格：	¥5225.00
规格：	50 µl	价格：	¥4125.00

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