孟德尔分析审稿意见求助

求助丁香园的各位大佬们，前段时间投了一篇孟德尔分析文章，审稿人1两个问题不是很明白，第一个问题是想问我选择这些SNP的依据吗？还是问我选的SNP和结局相关要剔除？第二个问题是希望我再用meta分析验证结果？那我感觉和孟德尔分析的意义一样吧？

拜托各位大佬们帮我看看这需要怎么回复呀

1. Why the authors choose the impact of selected SNPs with the progression of the disease.

2. I recommended that the authors performed a meta-analysis work to justify the findings.