Analysis of Gene Promoter Regulation by Tumor Suppressor Genes

Gene expression is controlled at several steps. Transcription is one of the important steps at which regulation occurs. Tumor suppressors such as p53, which are basically transcription factors, carry out their function primarily by the transcriptional activation of the target genes. The promoter region of a gene plays a major role in its transcriptional regulation, so it would be very useful for laboratories involved in the study of the tumor suppressor function to know the techniques used to analyze the regulation of gene promoters, particularly if they encode transcription factors.