CD35分子
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CD35 分子
CD35
常用单克隆抗体或代号： TO5,E11;(CR1)
主要表达细胞： G,M,DC,B,NKsubRBC [M]
分子质量(kDa)和结构： p250(含CCP结构域)
功 能： 结合C3b和C4b,调理吞噬,红细胞免疫粘附,调节B细胞活化
CD35
Aka CR1, C3b and C4b receptor
Mediates adherence of immune complexes coated with C4b/C3b and their transport to the fixed phagocyte systems of the spleen and liver
Cofactor for specific proteolytic cleavage of C3b and C4b by plasma serine protease factor I, which limits complement activation and produces ligands for other complement receptors
The Knops, McCoy, Swain-Langley, and York blood group antigens are located on CD35
Positive staining: granulocytes, macrophages, B cells, T cells (10%), NK cell subset, erythrocytes, follicular dendritic cells, eosinophils, glomerular podocytes, some astrocytes
Micro images (AJSP subscribers): inflammatory pseudotumor-like follicular dendritic cell tumor A, B
Micro images (Mod Path subscribers): extranodal follicular dendritic cell sarcoma (figure 7B)
Reference: AJSP 2001;25:721, Mod Path 2002;15:50
