Software for Genetic Linkage Analysis
互联网
670
Gene mapping by the analysis of traits segregating in human pedigrees is a major goal of linkage analysis (1 ), itself firmly rooted in the statistical technique of maximum-likelihood estimation (MLE; 2 ). The quantity estimated is most often the recombination fraction (ϑ), using the now well-known lod-score method (ref. 3 and Chapter 29 , this volume).
