• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Linkage Analysis of Genetic Disorders

        互联网

        400
        Genetic disorders follow a classic Mendelian dominant or recessive single-locus pattern of inheritance or a complex genetic pattern (multiple genes and environmental influences). In general, the complexity arises when the simple correspondence between genotype and phenotype is not one to one due to possible misclassification of phenotype, incomplete and age-dependent penetrance, phenocopies, genetic heterogeneity and/or oligogenic inheritance. Errors in diagnosis could be the result of variable expression of a disease with mildly affected individuals being misdiagnosed as unaffected. In the presence of incomplete or age-dependent penetrance, an individual who inherits a predisposing disease allele may not manifest the disease at all or the chance of manifesting the disease may depend on his or her age. On the other hand, phenocopies are individuals who do not inherit the disease allele but have the disease in question, probably caused by environmental factors and/or other genes. Genetic heterogeneity is a situation where mutations in any one of several genes may result in identical phenotype. Oligogenic inheritance requires the simultaneous presence of mutations in multiple genes.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序