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        Establishment of Ovarian Cancer Cell Lines

        互联网

        634
        Human tumor cell lines have provided valuable model systems to study a wide variety of tumor characteristics including the cell biology, genetics, and chemosensitivity profiles of disease. A large number of ovarian cancer cell lines have now been established and are in widespread use Table 1 ) (1 -15 ). Many of these have been selected to reflect specific situations, e.g., pre- and postchemotherapy models or different histo- logical subtypes.
        Table 1  Properties of Established Ovarian Carcinoma Cell Lines
             

        Prior

        		  

        Cell Line

        Histology

        Source

        Treatment

        Ref.

        PE01

        P.D. Serous adenoca

        Ascites

        P/FU/CHL

        1

        PE04

        P.D. Serous adenoca

        Ascites

        P/FU/CHL

        1

        PE06

        P.D. Serous adenoca

        Ascites

        P/FU/CHL

        2

        PEA1

        P.D. Adenoca

        Pleural

        None

        2

        PEA2

        P.D. Adenoca

        Ascites

        P/Pred

        2

        PE016

        P.D. Serous adenoca

        Ascites

        Radioth

        2

        PE014

        W.D.Serous adenoca

        Ascites

        None

        2

        T014

        W.D.Serous adenoca

        Sol. Met

        None

        2

        PE023

        W.D.Serous adenoca

        Ascites

        P/CHL

        2

        SKOV-3

        Adenoca

        Ascites

        T

        3

        SW626

        Adenoca

        ―

        ―

        3

        OVCAR-2

        Adenoca

        Ascites

        P/Cy

        4

        OVCAR-3

        P.D. papillary adenoca

        Ascites

        P/Cy/Adr

        5

        OVCAR-4

        Adenoca

        Ascites

        P/Cy/Adr

        6

        OVCAR-5

        Adenoca

        Ascites

        None

        7

        OAW 28

        Adenoca

        Ascites

        P / Mel

        8

        OAW 42

        Serous adenoca

        Ascites

        P

        8

        41M

        Adenoca

        Ascites

        None

        9

        59M

        Endometr adenoca

        Ascites

        None

        8

        CH1

        Papillary adenoca

        Ascites

        P/ JM8

        8

        138D

        Serous adenoca

        Ascites

        Carb

        9

        180D

        Adenoca

        Ascites

        P

        9

        200D

        Serous adenoca

        Solid

        None

        9

        253D

        Serous adenoca

        Ascites

        Cy/MPA

        9

        HOC-1

        W.D. Serous adenoca

        Ascites

        None

        10

        HOC-7

        W.D. Serous adenoca

        Ascites

        None

        10

        CAOV-3

        Adenoca

        Tumour

        Cy/Adr/FU

        10

        COLO 110

        Serous adenoca

        Sol. Met

        None

        11

        COLO 316

        Serous adenoca

        Pleural

        None

        11

        COLO 319

        Serous adenoca

        Ascites

        None

        11

        COLO 330

        Serous adenoca

        Ascites

        Mel/Radiother

        11

        IGROV1

        Adenoca

        Primary

        None

        12

        HTOA

        W.D. serous adenoca

        Primary

        None

        13

        OV-1063

        Papillary adenoca

        Ascites

        Cy/Adr/P/HMM

        14

        DO-s

        W.D. mucinous adenoca

        Ascites

        ―

        15
        P.D. = Poorly differentiated; W.D. = Well differentiated; adenoca = adenocarcinoma; pleural = pleural effusion; Sol.met. = solid metastasis; P = cisplatin; FU = 5-fluorouracil; CHL = chlorambucil; Pred = prednimustine; Radioth = radiotherapy; T = thiotepa; Cy = cyclophosphamide; Adr = adriamycin; Mel = melphalan; Carb = carboplatin; MPA = medroxyprogesterone actetate; HMM = examethylmelamine.
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