Generation of Recombinant SV40 Vectors for Gene Transfer

The field of gene therapy has evolved from an investigative curiosity to a major focus of medical research. To date, however, its clinical successes have been few. There are many reasons for this lack of success in clinical studies, but among the most important of these is the inadequacy of gene-delivery vectors, both viral and nonviral. In part because of this problem, we began work on a system of viral gene-delivery vehicles based on SV40.