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位于肾皮质和肾柱内，呈球形，直径约 200微米，分血管极和尿极。由特殊的动脉性毛细血管球（肾小球）和包在其外面的肾小囊构成，是分泌尿液的部分。毛细血管球两端分别为入球及出球小动脉，一般前者管径较粗，均由血管极进出。肾小囊是肾小管的盲端膨大凹陷而成，分脏层与壁层，脏层细胞为有突起的足细胞，经基膜与肾小球的毛细血管内皮细胞紧密接触。足细胞、基膜、内皮细胞构成肾小球的滤过膜。壁层由单层扁平细胞构成，与肾小管壁相连续。壁、脏层之间为肾小囊腔，在尿极移行为肾小管。
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