Polymorphonuclear Leukocyte Locomotion
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Chemotaxis and random migration of polymorphonuclear leukocytes can be determined in the presence of test chemicals. A change
in the chemotactic index provides an indication of the cytotoxicity of compounds. The migration of polymorphonuclear leukocytes
to the site of injury is an integral part of the inflammation process in vivo. Any compound that inhibits this locomotion,
either by a direct cytotoxic effect or by interference with the chemotactic stimulus, would severely compromise the inflammation
process of an individual. The Boyden chamber filter membrane method has been shown to be a simple in vitro method for studying
the migration of PMN
and examining the influence of chemicals on that migration. The chemotactic index gives an indication of the level of toxic
effects of compounds on locomotion.
