Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo: The Antisense Effects Outlast Antisense Survival

Standard chemotherapy for cancer usually is accompanied by systemic tox icity, reflecting the large number of cellular targets affected by the chemo therapeutic agent. in principle, an antisense oligonucleotide targeted at a gene essential for neoplastic cell growth should interfere with only that gene’s expression, resulting in arrest of cancer cell growth.