CD13分子
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CD13 分子
CDl3
常用单克隆抗体或代号：MY7，MOU28
主要表达细胞：M，G，En，Ep[M]
分子质量(kDa)和结构：gp150一170(Ⅱ型膜分子)
功 能：氨肽酶，冠状病毒受体，参与人CMV与靶细胞的结合，抗CDl3自身抗体与GVHD有关
CD13
Aka AminoPeptidase N, APN
Myeloid antigen, although CD33 is more specific
Peptide cleaving enzyme of brush border membranes of small intestine, renal proximal tubules and placenta
Also present on CNS synaptic membranes
Receptor for one strain of human coronavirus that causes many upper respiratory tract infections
Defects appear to cause various leukemias/lymphomas
Serves an important function for early CMV infection
CD13 autoantibodies are strongly associated with chronic graft versus host disease after bone marrow transplantation
Positive staining (normal): bile duct canaliculi, central nervous system synapses, endothelial cells, fibroblasts, granulocytes (most), large granular lymphocytes (some), macrophages, osteoclasts, perineurium of peripheral nerves, placenta, renal proximal tubules, small intestine
Positive staining (disease): AML M1-M5 (75-95%), M6 (usually), CML (90%); pre B ALL (7-10%), pre T ALL (rare)
