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        Generating Human Osteoclasts from Peripheral Blood

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        Osteoclasts are large multinucleated cells that are uniquely specialized for the function of lacunar bone resorption. For much of the previous century osteoclasts were thought to share a common progenitor cell with osteoblasts, bone-forming cells. Osteoclast formation occurring as a consequence of fusion of nonosteoblastic mononuclear precursor cells was suggested by a number of early investigators including Pommer (1883), Mallory (1912), La Coste (1923), and Hancock (1949) (for review see ref. 1 ). It was subsequently established by numerous studies that osteoclasts are derived from a hematopoietic marrow precursor (2 ). These studies included parabiosis experiments in which normal and affected (osteopetrotic/radiation-treated) littermates are linked by a common circulation; these experiments established that the mononuclear osteoclast precursor is present in peripheral blood (3 ,4 ).
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