CD6分子
互联网
2005
CD6 分子
常用单克隆抗体或代号：T12，T411
主要表达细胞：TsuL，Bsub，Thy[T]
分子质量(kDa)和结构：gp100(清除剂受体)
功 能：配体CDl66，T细胞活化，胸腺细胞与基质细胞相互作用
Adhesion molecule mediating the binding of developing thymocytes with thymic epithelial cells
May be involved in autoimmunity and graft vs. host disease (GVHD)
Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent GVHD
Positive staining (normal): low levels on immature thymocytes, high levels on mature thymocytes
