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        CD31分子

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        2888
        CD31 分子
         
        CD31
         
        常用单克隆抗体或代号: SG134,TM3,HEC- 75;(PECAM、EndoCAM)
         
        主要表达细胞: Pt,M,G,B,NK,Tsub [AS]
         
        分子质量(kDa)和结构: gp140,血小板GPⅡa(IgSF)
         
        功    能: 嗜同性或嗜异性(与CD38互为受体)粘附,炎症,En功能
         
        CD31
        Aka platelet endothelial cell adhesion molecule, PECAM-1
        Encoded on #17
        Most sensitive and specific endothelial marker in paraffin sections
        Important role in diapedesis step of leukocyte emigration in inflammation; also angiogenesis
        Note: don’t confuse CD31+ macrophages (granular, membranous expression) with a vascular tumor, AJSP 2001;25:1167
        Sensitive for malignant vascular tumors; may be less sensitive for benign lesions
        Interpretation: membranous stain (not cylasmic); endothelium is a positive internal control
        Positive staining (normal): endothelium, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts, neutrophils
        Positive staining (tumors): epithelioid hemangioendothelioma; epithelioid sarcoma-like hemangioendothelioma (AJSP 2003;27:48); other vascular tumors, histiocytic malignancies, plasmacytomas; rare carcinomas and sarcomas
        Micro images: epithelioid angiosarcoma (figure 1A)
        Micro images (AJSP subscribers): epithelioid sarcoma-like hemangioendothelioma, epithelioid hemangioendothelioma, epithelioid angiosarcoma, CD31+ macrophages, malignant histiocytosis
        Micro images (Hum Path subscribers): hepatic cavernous hemangiomas (figure 2B)
        Micro images (Mod Path subscribers): angiosarcoma (figure E)
        References:  AJSP 2001;25:684, Mod Path 2002:15;434

         
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